Dr. Kumar Swamy Reddy N

DST-INSPIRE Faculty

Areas of Interest

• Heterogeneous Catalysis
• Asymmetric Catalysis
• Synthetic Methodology
• Peptides and Protein Chemistry
• Biorthogonal Chemistry
• Fluorescent Labelling

Education

• Ph.D., Indian Institute of Technology Madras, India
• MSc (Organic Chemistry)., Sri Venkateswara University, Tirupati.
• Postdoc., Institute of Transformative Bio-Molecules (ITbM), Nagoya University, Japan with Prof. Jeffrey W Bode (ETH Zurich, Switzerland).

Latest Publications

• Kumarswamyreddy, N.; Nakagawa A; Endo H; Shimotohno A; Torii K. U; Bode J. W*; Oishi S*; “Chemical Synthesis of the EPF-Family of Plant Cysteine-Rich Proteins and Late-Stage Dye Attachment by Chemoselective Amide-Forming Ligations”. RSC Chem.Biol., 2022, (accepted) https://pubs.rsc.org/en/Content/ArticleLanding/2022/CB/D2CB00155A
• Lokesh, K.; Kumarswamyreddy, N.*.; Kesavan, V. “Diastereoselective Construction of Tetrahydro-Dispiro[indolinone-3,2′-pyran-5′,4″-pyrazolone] Scaffolds via an Oxa-Michael Cascade [4 + 2] Annulation Reaction”. J. Org. Chem. 2022,(accepted); https://doi.org/10.1021/acs.joc.2c01370 (*Corresponding Author)
• Kumarswamyreddy, N.; Reddy, D. N.; Robkis, D. M.; Kamiya, N.; Tsukamoto, R.; Kanaoka, M. M.; Higashiyama, T.; Oishi, S.; Bode, J. W.; “Chemical Synthesis of Torenia Plant Pollen Tube Attractant Proteins by KAHA Ligation”. RSC Chem. Biol. 2022, accepted. https://doi.org/10.1039/D2CB00039C
• Muthusamy, S.; Kumarswamyreddy, N*.; Kesavan, V.; "Enantioselective Synthesis of 3-Amino-3’-carbazole Oxindole Derivatives via Friedel-Crafts Aminoalkylation Reaction". ChemistrySelect, 2022, 7, e202200131 (*Corresponding Author). https://doi.org/10.1002/slct.202200131
• Kumarswamyreddy, N*.;Jayakumar, S.; Kesavan, V.; "Palladium-catalyzed Asymmetric Allylic Alkylation of 3-Amino-2-Oxindoles: Synthesis of 3-Allyl-3-Amino-2-Oxindoles". Tetrahedron Lett., 2021, in press (*Corresponding Author). https://doi.org/10.1016/j.tetlet.2021.153385.
• Pratap Reddy Gajulapalli, V.; Kumarswamyreddy, N*.; Lokesh, K.; Kesavan, V.; "Enantioselective Synthesis of 3-Acetyl Coumarin Substituted 3-Hydroxy Oxindoles and Pyranocoumarin Fused Spirooxindoles". ChemistrySelect., 2021, 6 (31), 7855-7859 (*Corresponding Author). https://doi.org/10.1002/slct.202102495.
• Kumarswamyreddy, N.; Lokesh, K.; Kesavan, V.; “Efficient Synthesis of Highly Functionalized Indole and Phenol Containing 3,3′-Disubstituted Oxindoles and Chromene Fused Spirooxindoles” Tetrahedron Lett., 2018, 59, 4344-4348.
• Sivamuthuraman, K.; Kumarswamyreddy, N.; Kesavan, V., “Diastereo-and Enantioselective Synthesis of 2,2-Disubstituted Benzofuran-3-one Bearing Adjacent Quaternary and Tertiary Stereocenters” J. Org. Chem. 2017, 82, 10812-10822.
• Shilpa T.; Kumarswamyreddy, N.; Prakash M.; Kesavan V.; Ganesh V and Suresh K. R. “DHQZ-17,A Potent Inhibitor of the Transcription Factor HNF4A, Suppresses Tumorigenicity of Head & Neck Squamous Cell Carcinoma in vivo.” J Cell Physiol. 2017; 233, 2613 – 2628.
• Kumarswamyreddy, N.; Kesavan, V. “Stereoselective and Regioselective Assembly of Spirooxindole Fused 2,1-b]furan Motifs Through a Tandem Friedel-Crafts Alkylation/5-exodig- Cyclization.” Eur. J. Org. Chem. 2016, 5301-5308.
• Kumarswamyreddy, N.; Kesavan, V. “Enantioselective Synthesis of Dihydrospiro [indoline-3,4'-pyrano[2,3-c]pyrazole] Derivatives via Michael/Hemiketalization Reaction.” Org. Lett. 2016, 18, 1354-1357.
• Muthusamy, S.; Kumarswamyreddy, N.; Kesavan, V.; Chandrasekaran S. “Recent Advances in Aerobic Oxidation with Ruthenium Catalysts.” Tetrahedron Lett., 2016, 57, 5551-5559 (Digest paper).
• Kumarswamyreddy, N.; Prakash, M.; Jayakumar, S.; Kesavan, V. “Assembly of 3-allyl-3- ethynyl-oxindole Motifs via Palladium(II)-catalyzed Quaternary Allylation of 3-ethynyl-3- OBoc-oxindoles.” RSC Adv. 2015, 5, 54316-54320.
• Jayakumar, S.; Kumarswamyreddy, N.; Prakash, M.; Kesavan, V. “Palladium Catalyzed Asymmetric Allylation of 3-OBoc-Oxindoles: An Efficient Synthesis of 3-Allyl-3- hydroxyoxindoles.” Org. Lett. 2015, 17, 1066-1069.